v0.5.0 Released: Validation & Benchmark Infrastructure | AD ground truth, mock APIs, swappable fine-mapping, 1,356 tests | DOI: 10.5281/zenodo.19420648 → 🧬 AI Agents for Health: ClawBio Hackathon | Thu 23 April 2026, 12:00-19:00 | University of Westminster, London | Register: luma.com/8qtu0xaz →
v0.5.0 · 744 stars · 145 forks · 55 skills · 1,356 tests · Claude Code plugin

The first bioinformatics-native
AI agent skill library

ClawBio is where biological AI gets its skills: a curated, reproducible, open repository any agent can call.

⭐ View on GitHub 🎮 Join Discord 💬 Join Telegram 🧬 Submit a Skill 🤖 Try RoboTerri on Telegram
bioinformaticsgenomicsreproducibilitypopulation-geneticsequityai-agentslocal-firstopenclaw

NutriGx Advisor — community-contributed skill running locally on raw genetic data

The Problem
Reproducing bioinformatics analyses is broken
# Without ClawBio
$ git clone repo && cd repo
# Wrong Python version...
# Reference data link is dead...
# Paths hardcoded to /home/jsmith/data/
# Email first author. Wait 3 weeks.
# Give up.
  • ✗ Dependency hell & broken environments
  • ✗ Dead links to reference data
  • ✗ Hardcoded paths & missing configs
  • ✗ AI hallucinates star alleles & outdated guidelines
  • ✗ No audit trail, no checksums
# With ClawBio
$ python ancestry_pca.py --demo --output fig3

✓ Figure 3 reproduced.
✓ Identical. SHA-256 verified.
✓ 30 seconds.

# Or with natural language:
$ openclaw "Profile my pharmacogenes"

Every skill exports commands.sh, environment.yml, and SHA-256 checksums — anyone can reproduce without the agent.

Why ClawBio
Domain expertise, frozen into code

ChatGPT and Claude are smart generalists. ClawBio skills are domain experts' proven pipelines — executed correctly every time.

🏠
Local-first
Your genomic data never leaves your laptop. No cloud uploads, no data exfiltration. Full privacy by design.
🔁
Reproducible
Every analysis exports a reproducibility bundle — commands, environment, and SHA-256 checksums. Reproduce without the agent.
🧩
Modular
Each skill is a self-contained directory (SKILL.md + Python scripts) that plugs into the orchestrator — or runs standalone.
⚖️
MIT Licensed
Open-source, free, community-driven. Clone it, run it, build a skill, submit a PR.
🌍
Equity-aware
Built-in support for underrepresented populations. HEIM diversity metrics baked into the roadmap.
🎯
Benchmark Validated
AD ground truth (34 genes, 3 evidence tiers), mock API server for offline CI, swappable fine-mapping (ABF vs SuSiE), benchmark scorer with precision/recall/F1. 74 benchmark tests. DOI: 10.5281/zenodo.19420648
🦞
Built on OpenClaw
Powered by OpenClaw (180k+ GitHub stars) — the agent platform that routes natural language to the right specialist skill.
🔌
Claude Code Plugin
Install with two commands: /plugin marketplace add ClawBio/ClawBio then /plugin install clawbio. All skills instantly available.
Skills Library
55 skills · 21 production-ready · 1,356 tests

Each skill includes demo data so you can try it immediately without your own files.

💊 PharmGx Reporter
Pharmacogenomic report from 23andMe/AncestryDNA: 12 genes, 31 SNPs, 51 drugs, CPIC guidelines.
MVP
🔍 GWAS Lookup
Federated variant lookup across 9 genomic databases: GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.
MVP
🔬 scRNA Orchestrator
Local Scanpy pipeline for single-cell RNA-seq: QC, doublet detection, clustering, marker discovery, cell-type annotation.
MVP
📊 GWAS Polygenic Risk
Calculate polygenic risk scores from DTC genetic data using curated PGS Catalog scores across 6 traits.
MVP
⚖️ Equity Scorer
Compute HEIM diversity and equity metrics from VCF or ancestry data: heterozygosity, FST, and population representation scores.
MVP
🥗 NutriGx Advisor
Personalised nutrition report from consumer genetic data (23andMe, AncestryDNA, VCF): MTHFR, folate, vitamin D, lactose, omega-3.
MVP
🧬 Genome Compare
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture.
MVP
💉 ClinPGx
Query the ClinPGx API for pharmacogenomic gene-drug data, CPIC guidelines, clinical annotations, and FDA drug labels.
MVP
🔭 Galaxy Bridge
Galaxy tool discovery, intelligent recommendation, and execution: 8,000+ bioinformatics tools from usegalaxy.org with multi-signal scoring and workflow suggestions.
MVP
📈 RNA-seq DE
Differential expression for bulk RNA-seq and pseudo-bulk count matrices with QC, PCA, volcano plots, and contrast reporting.
MVP
🏦 UKB Navigator
Semantic search across UK Biobank's 12,000+ data fields and publications: find the right variables for your analysis.
MVP
📷 Drug Photo
Snap a photo of any medication packaging. ClawBio identifies the drug, queries your pharmacogenomic profile, and returns a personalised dosage card.
MVP

+ 43 more skills on GitHub

In Production
ClawBio skills, running in conversation

ClawBio skills aren't just CLI tools — they power live AI agents that talk to real users every day.

RoboTerri avatar
RoboTerri
Telegram AI Agent
A bioinformatics intelligence agent on Telegram — inspired by Professor Teresa K. Attwood, a pioneer of bioinformatics education and research. Run pharmacogenomics reports from your own genetic data. Snap a photo of your medication, get personalised dosage guidance. All local-first, all reproducible.
PharmGx Reporter Drug Photo Lookup NutriGx Advisor Genome Compare Equity Scorer Metagenomics GWAS Lookup scRNA Orchestrator
Community
Wanted: skills from the community

If you work with genomics, proteomics, metabolomics, imaging, or clinical data — wrap your pipeline as a skill.

claw-gwas
PLINK/REGENIE automation — Statistical genetics
claw-acmg
Clinical variant classification — Clinical genomics
claw-pathway
GO/KEGG enrichment — Functional genomics
claw-phylogenetics
IQ-TREE/RAxML automation — Evolutionary biology
claw-spatial
Visium/MERFISH — Spatial transcriptomics
claw-long-reads
ONT/PacBio QC and assembly — Long-read sequencing
+
Your skill here
🎮 Join the Discord 💬 Join the Telegram 📖 Read the contribution guide
Ecosystem
2,100+ skills across 9 repositories

Open-source biology skill repos from Stanford, Imperial, and the community.

Repo OpenClaw Stars Forks Skills
ClawBio✓74414555
OpenClaw-Medical-Skills✓1,037123869
bioSkills✓33152425
LabClaw✓31754211
claude-scientific-skills~14.5k1,585250
Biomni—2,826508314

View all 9 repos in the full marketplace →

Recent Updates
Latest from the community
🌊
flow-bio: new skill bridges the Flow.bio API so you can browse samples, executions, projects, and pipelines, search across metadata, and upload new samples directly from ClawBio. 25 passing tests.
PR #76 · 22 April 2026
🧬
proteomics-clock: new skill computes organ-specific biological age from Olink NPX proteomic data using Goeminne et al. (2025) elastic net aging clocks across 23 organs, with Gen1 and Gen2 (Gompertz) clock variants. 10 passing tests.
PR #119 · 22 April 2026
🗂️
turingdb-graph: new skill builds, queries, and analyses biomedical knowledge graphs in TuringDB (a columnar graph database with git-like versioning), with CSV/GML/JSONL ingest and cohort analytics. 7 smoke tests.
PR #145 · 22 April 2026

View all merged pull requests on GitHub →

Get started in 30 seconds

Install as a Claude Code plugin or clone from source — every skill includes demo data.

# Option 1: Claude Code plugin (fastest)
/plugin marketplace add ClawBio/ClawBio
/plugin install clawbio

# Option 2: Clone and install
git clone https://github.com/ClawBio/ClawBio.git && cd ClawBio
pip install -r requirements.txt
python clawbio.py run pharmgx --demo
⭐ Star on GitHub 🤖 Try RoboTerri 📄 Documentation