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574 stars · 106 forks · 41 skills · 15 contributors · Claude Code plugin

The first bioinformatics-native
AI agent skill library

ClawBio is where biological AI gets its skills: a curated, reproducible, open repository any agent can call.

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bioinformaticsgenomicsreproducibilitypopulation-geneticsequityai-agentslocal-firstopenclaw

NutriGx Advisor — community-contributed skill running locally on raw genetic data

The Problem
Reproducing bioinformatics analyses is broken
# Without ClawBio
$ git clone repo && cd repo
# Wrong Python version...
# Reference data link is dead...
# Paths hardcoded to /home/jsmith/data/
# Email first author. Wait 3 weeks.
# Give up.
  • ✗ Dependency hell & broken environments
  • ✗ Dead links to reference data
  • ✗ Hardcoded paths & missing configs
  • ✗ AI hallucinates star alleles & outdated guidelines
  • ✗ No audit trail, no checksums
# With ClawBio
$ python ancestry_pca.py --demo --output fig3

✓ Figure 3 reproduced.
✓ Identical. SHA-256 verified.
✓ 30 seconds.

# Or with natural language:
$ openclaw "Profile my pharmacogenes"

Every skill exports commands.sh, environment.yml, and SHA-256 checksums — anyone can reproduce without the agent.

Why ClawBio
Domain expertise, frozen into code

ChatGPT and Claude are smart generalists. ClawBio skills are domain experts' proven pipelines — executed correctly every time.

🏠
Local-first
Your genomic data never leaves your laptop. No cloud uploads, no data exfiltration. Full privacy by design.
🔁
Reproducible
Every analysis exports a reproducibility bundle — commands, environment, and SHA-256 checksums. Reproduce without the agent.
🧩
Modular
Each skill is a self-contained directory (SKILL.md + Python scripts) that plugs into the orchestrator — or runs standalone.
⚖️
MIT Licensed
Open-source, free, community-driven. Clone it, run it, build a skill, submit a PR.
🌍
Equity-aware
Built-in support for underrepresented populations. HEIM diversity metrics baked into the roadmap.
🦞
Built on OpenClaw
Powered by OpenClaw (180k+ GitHub stars) — the agent platform that routes natural language to the right specialist skill.
🔌
Claude Code Plugin
Install with two commands: /plugin marketplace add ClawBio/ClawBio then /plugin install clawbio. All skills instantly available.
Skills Library
41 skills · 20 production-ready

Each skill includes demo data so you can try it immediately without your own files.

💊 PharmGx Reporter
Pharmacogenomic report from 23andMe/AncestryDNA: 12 genes, 31 SNPs, 51 drugs, CPIC guidelines.
MVP
🔍 GWAS Lookup
Federated variant lookup across 9 genomic databases: GWAS Catalog, Open Targets, PheWeb, GTEx, gnomAD, ClinVar, EBI, TogoVar.
MVP
🔬 scRNA Orchestrator
Local Scanpy pipeline for single-cell RNA-seq: QC, doublet detection, clustering, marker discovery, cell-type annotation.
MVP
📊 GWAS Polygenic Risk
Calculate polygenic risk scores from DTC genetic data using curated PGS Catalog scores across 6 traits.
MVP
⚖️ Equity Scorer
Compute HEIM diversity and equity metrics from VCF or ancestry data: heterozygosity, FST, and population representation scores.
MVP
🥗 NutriGx Advisor
Personalised nutrition report from consumer genetic data (23andMe, AncestryDNA, VCF): MTHFR, folate, vitamin D, lactose, omega-3.
MVP
🧬 Genome Compare
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture.
MVP
💉 ClinPGx
Query the ClinPGx API for pharmacogenomic gene-drug data, CPIC guidelines, clinical annotations, and FDA drug labels.
MVP
🧫 Bioconductor Bridge
Bioconductor package discovery, workflow recommendation, setup inspection, and R starter code generation.
MVP
📈 RNA-seq DE
Differential expression for bulk RNA-seq and pseudo-bulk count matrices with QC, PCA, volcano plots, and contrast reporting.
MVP
🏦 UKB Navigator
Semantic search across UK Biobank's 12,000+ data fields and publications: find the right variables for your analysis.
MVP
🗺️ Profile Report
Unified personal genomic profile report combining PGx, nutrigenomics, ancestry, and polygenic risk insights in one document.
MVP

+ 29 more skills on GitHub

In Production
ClawBio skills, running in conversation

ClawBio skills aren't just CLI tools — they power live AI agents that talk to real users every day.

RoboTerri avatar
RoboTerri
Telegram AI Agent
A bioinformatics intelligence agent on Telegram — inspired by Professor Teresa K. Attwood, a pioneer of bioinformatics education and research. Run pharmacogenomics reports from your own genetic data. Snap a photo of your medication, get personalised dosage guidance. All local-first, all reproducible.
PharmGx Reporter Drug Photo Lookup NutriGx Advisor Genome Compare Equity Scorer Metagenomics GWAS Lookup scRNA Orchestrator
Community
Wanted: skills from the community

If you work with genomics, proteomics, metabolomics, imaging, or clinical data — wrap your pipeline as a skill.

claw-gwas
PLINK/REGENIE automation — Statistical genetics
claw-acmg
Clinical variant classification — Clinical genomics
claw-pathway
GO/KEGG enrichment — Functional genomics
claw-phylogenetics
IQ-TREE/RAxML automation — Evolutionary biology
claw-spatial
Visium/MERFISH — Spatial transcriptomics
claw-long-reads
ONT/PacBio QC and assembly — Long-read sequencing
+
Your skill here
🎮 Join the Discord 💬 Join the Telegram 📖 Read the contribution guide
Ecosystem
2,100+ skills across 9 repositories

Open-source biology skill repos from Stanford, Imperial, and the community.

Repo OpenClaw Stars Forks Skills
ClawBio✓57410641
OpenClaw-Medical-Skills✓1,037123869
bioSkills✓33152425
LabClaw✓31754211
claude-scientific-skills~14.5k1,585250
Biomni—2,826508314

View all 9 repos in the full marketplace →

Recent Updates
Latest from the community
💊
PharmGx Reporter: MTHFR support and MyHeritage DNA compatibility
Contributed by camlloyd · 2 April 2026
📓
Colab notebooks: interactive tutorials for first skill and GWAS analysis
Added by ClawBio team · 2 April 2026
🧬
clinical-variant-reporter: ACMG/AMP variant classification skill
Contributed by RezaJF · 29 March 2026

View all merged pull requests on GitHub →

Get started in 30 seconds

Install as a Claude Code plugin or clone from source — every skill includes demo data.

# Option 1: Claude Code plugin (fastest)
/plugin marketplace add ClawBio/ClawBio
/plugin install clawbio

# Option 2: Clone and install
git clone https://github.com/ClawBio/ClawBio.git && cd ClawBio
pip install -r requirements.txt
python clawbio.py run pharmgx --demo
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